Family

FAM105 (IPR023235)

Short name: FAM105

Overlapping homologous superfamilies

None.

Family relationships

Description

This entry represents the FAM105 family, including FAM105A (OTULINL) and FAM105B (OTULIN). Otulin is an ubiquitin thioesterase that specifically removes linear ('Met-1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response [PMID: 23708998]. FAM105A shares a high degree of similarity with protein otulin; however, FAM105A lacks the conserved active site at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity [PMID: 23708998].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PRINTS
Pfam