Homologous Superfamily

Salmonella invasion protein A, C-terminal actin-binding domain superfamily (IPR023224)

Short name: SipA_actin-bd_C_sf

Description

Salmonella invasion protein A (SipA) is a virulence factor that is translocated into host cells by a type III secretion system. In the host cell it binds to actin, stimulates actin polymerisation and counteracts F-actin destabilising proteins. This contributes towards cytoskeletal rearrangements that allow the entry of the pathogen into the host cell [PMID: 11331579].

The actin-binding domain forms a heart-shaped helical structure that appears to be unrelated to that of other actin-binding domains [PMID: 14512630]. Disordered regions are present on both sides of the structural domain, forming nonglobular arms. SipA polymerises actin by stapling filaments with these nonglobular arms.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
SUPERFAMILY