Nitrophenylphosphatase-like domain (IPR023215)

Short name: NPhePase-like_dom

Domain relationships



The haloacid dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification [PMID: 7966317].

Crystal structures of proteins from the HAD superfamily show that these proteins all share a conserved alpha/beta-domain classified as a hydrolase fold, which is similar to the Rossmann fold [PMID: 14555659]. This conserved domain usually contains an insertion domain. The insertion domain shows structural variation among the different functional classes of the haloacid dehalogenase superfamily.

This entry represents a Rossmann fold insertion domain found in some HAD members, including 4-nitrophenylphosphatase.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.