Homologous Superfamily

Ribosome modulation factor-like domain superfamily (IPR023200)

Short name: Ribosome_modulation_factor_dom

Overlapping entries


This superfamily represents the structural domain of ribosome modulation factors (RMF). They associate with 70s ribosomes and convert them to a dimeric form (100S ribosomes) which appear during the transition from the exponential growth phase to the stationary phase of Escherichia coli cells [PMID: 8440252, PMID: 2181444].

It has been proposed that RMF mediates the formation of a 'storage ribosome', the 100S particle, in stationary phase by inactivating excess ribosomes to protect them from degradation and to maintain the required balance between the concentrations of ribosomes and protein synthesis factors in order to maintain translational elongation efficiency [PMID: 16088400, PMID: 17185553].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.