Homologous Superfamily

Copper chaperone GriE/MELC1 superfamily (IPR023199)

Short name: GriE/MELC1_sf

Overlapping entries


This superfamily represents the 2-layer alpha/beta sandwich domain of tyrosinase co-factor MELC1 and copper chaperone GriE [PMID: 16282322].

The melanin operon (melC) of Streptomyces antibioticus contains two genes, melC1 and melC2 (apotyrosinase). It is thought that MelC1 forms a transient binary complex with the downstream apotyrosinase MelC2 to facilitate the incorporation of copper ion and the secretion of tyrosinase indicating that MelC1 is a chaperone for the apotyrosinase MelC2 [PMID: 8360164].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.