Homologous Superfamily

Phosphoserine phosphatase, domain 2 (IPR023190)

Short name: Pser_Pase_dom_2

Overlapping entries


Phosphoserine phosphatases (PSP) are members of a large group of enzymes responsible for phosphoester hydrolysis using a phosphoaspartate-enzyme intermediate. Reversible protein phosphorylation is essential for regulation of basic cell function such as DNA replication, gene transcription and protein translation. The phosphoserine phosphatases are related to the P-type ATPases and haloacid dehydrogenases, with which they share 3 conserved sequence motifs [PMID: 10567362].

The crystal structures of PSP, PSP in complex with its substrate and in complex with a transition state analogue have been solved, giving extensive insight into the catalytic mechanism of phosphoserine phosphatases [PMID: 12051918]. This superfamily represents the second domain, which is predominantly alpha helical.

GO terms

Biological Process

GO:0006564 L-serine biosynthetic process

Molecular Function

GO:0004647 phosphoserine phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.