Conserved Site

DNA-binding protein Dps, conserved site (IPR023188)

Short name: DPS_DNA-bd_CS


Escherichia coli protein Dps [PMID: 1340475] is a DNA-binding protein, synthesized during prolonged starvation, that seems to protect DNA from oxidative damage. Dps binds DNA without any apparent sequence specificity. It is a protein of about 19 Kd that associates into a complex of 12 subunits forming two stacked hexameric rings.

Proteins similar to Dps have been found in other bacteria:

  • Bacillus subtilis protein MrgA.
  • Antigen TpF1/TyF1 from Treponema pallidum.
  • Haemophilus ducreyi fine tangled pili major subunit (gene ftpA).
  • Helicobacter pylori neutrophil-activating protein A (gene napA).
  • Listeria innocua non-heme iron-containing ferritin.
  • Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) nutrient-stress induced DNA binding protein (gene dpsA).
  • A low-temperature induced protein from Anabaena variabilis.
  • Haemophilus influenzae hypothetical protein HI1349.
  • Synechocystis sp. (strain PCC 6803) hypothetical protein Slr1894.
  • A hypothetical protein encoded in the 5' region of a gene coding for a bromoperoxidase, in plasmid pOP2621 of Streptomyces aureofaciens.

All these proteins share a conserved region of about 50 residues in their central region. This entry corresponds to two conserved sites derived from both extremities of that region.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016722 oxidoreductase activity, oxidizing metal ions

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns