Pathways & interactions
DNA-binding protein Dps, conserved site (IPR023188)
Short name: DPS_DNA-bd_CS
Escherichia coli protein Dps [PMID: 1340475] is a DNA-binding protein, synthesized during prolonged starvation, that seems to protect DNA from oxidative damage. Dps binds DNA without any apparent sequence specificity. It is a protein of about 19 Kd that associates into a complex of 12 subunits forming two stacked hexameric rings.
Proteins similar to Dps have been found in other bacteria:
- Bacillus subtilis protein MrgA.
- Antigen TpF1/TyF1 from Treponema pallidum.
- Haemophilus ducreyi fine tangled pili major subunit (gene ftpA).
- Helicobacter pylori neutrophil-activating protein A (gene napA).
- Listeria innocua non-heme iron-containing ferritin.
- Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) nutrient-stress induced DNA binding protein (gene dpsA).
- A low-temperature induced protein from Anabaena variabilis.
- Haemophilus influenzae hypothetical protein HI1349.
- Synechocystis sp. (strain PCC 6803) hypothetical protein Slr1894.
- A hypothetical protein encoded in the 5' region of a gene coding for a bromoperoxidase, in plasmid pOP2621 of Streptomyces aureofaciens.
All these proteins share a conserved region of about 50 residues in their central region. This entry corresponds to two conserved sites derived from both extremities of that region.