Homologous Superfamily

Yap1 redox domain superfamily (IPR023167)

Short name: Yap1_redox_dom_sf

Overlapping entries



The transcription factor Yap1 is a central regulator of the response to oxidative stress in Saccharomyces cerevisiae. In the active oxidized form, a nuclear export signal (NES) in the carboxy-terminal cysteine-rich domain is masked by disulphide-bond-mediated interactions with a conserved amino-terminal alpha-helix. Upon reduction of the disulphide bonds, Yap1 undergoes a change that exposes the NES and allows redistribution to the cytoplasm [PMID: 15318225]. This entry represents a redox-regulated domain superfamily of Yap1.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.