Homologous Superfamily

ApoC-II domain superfamily (IPR023121)

Short name: ApoC-II_dom_sf

Overlapping entries


This domain superfamily is found in apolipoprotein CII (apoC-II). ApoC-II is a surface constituent of plasma lipoproteins and the activator for lipoprotein lipase (LPL). It is therefore central for lipid transport in blood. Lipoprotein lipase is a key enzyme in the regulation of triglyceride levels in human serum [PMID: 10903476]. It is the C-terminal helix of apoCII that is responsible for the activation of LPL [PMID: 12590574]. The active peptide of apoC-II occurs at residues 44-79 and has been shown to reverse the symptoms of genetic apoC-II deficiency in a human subject [PMID: 10903476].

Micellar SDS, a commonly used mimetic of the lipoprotein surface, inhibits the aggregation of apoC-II and induces a stable structure containing approximately 60% alpha-helix. The first 12 residues of apoC-II are structurally heterogeneous but the rest of the protein forms a predominantly helical structure [PMID: 11331005].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.