Domain

Translation initiation factor IF- 2, domain 3 (IPR023115)

Short name: TIF_IF2_dom3

Domain relationships

None.

Description

Initiation factor 2 (IF-2) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-2 promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome. IF-2 is a protein of about 70 to 95 kDa that contains a central GTP-binding domain flanked by a highly variable N-terminal domain and a more conserved C-terminal domain. Some members of this group undergo protein self splicing that involves a post-translational excision of the intein followed by peptide ligation.

The function of IF-2 in facilitating the proper binding of initiator methionyl-tRNA to the ribosomal P site appears to be universally conserved, with an IF-2 homologue (aIF-2) present in archaea bacteria [PMID: 10200264] Methanopyrus kandleri.

This entry represents the domain 3 of IF-2. It consists of a alpha/beta/alpha structure with a core formed by a parallel beta-sheet of 4 strands [PMID: 11114334].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D
Pfam
SUPERFAMILY