Homologous Superfamily

D-aminoacylase, insert domain superfamily (IPR023100)

Short name: D-aminoacylase_insert_dom_sf

Overlapping entries


D-aminoacylase hydrolyses a wide variety of N-acyl derivatives of neutral D-amino acids, in a zinc-dependent manner. The enzyme is composed of a small beta-barrel domain and a larger catalytic alpha/beta-barrel that contains a short alpha/beta insert. The overall structure shares significant similarity to the alpha/beta-barrel amidohydrolase superfamily, in which the beta-strands in both barrels superimpose well [PMID: 12454005].

This superfamily represents the insert found in the catalytic domain. This insert, composed of two alpha helices and four beta strands, goes across the active site and is involved in substrate-mediated conformational change.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.