Domain

Metalloprotease catalytic domain, predicted (IPR023091)

Short name: MetalPrtase_cat_dom_prd

Domain relationships

None.

Description

This entry represents a domain found in a number of predicted metalloproteases. The crystal structure of the protein from the hyperthermophilic bacteria Aquifex aeolicus has been determined. The overall fold consists of one central alpha-helix surrounded by a four-stranded beta-sheet and four other alpha-helices. Structure-based homology analysis reveals a good resemblance to metalloproteases such as collagenases and gelatinases. However, experimental tests for collagenase and gelatinase-type function show no detectable activity under standard assay conditions [PMID: 12832766].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004222 metalloendopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D