Family

Orotate phosphoribosyltransferase (IPR023031)

Short name: OPRT

Overlapping homologous superfamilies

Family relationships

Description

Orotate phosphoribosyltransferase (OPRTase) is involved in the biosynthesis of pyrimidine nucleotides. In the pyrimidine synthesis pathway, OPRT catalyses the reversible phosphoribosyl transfer from 5'-phospho-alpha-D-ribose 1'-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5'-monophosphate (OMP) [PMID: 22075667]. The structures and properties of the OPRTases from different species have been described in several publications [PMID: 12872993, PMID: 9305779, PMID: 8720144, PMID: 8487307].

GO terms

Biological Process

GO:0006221 pyrimidine nucleotide biosynthetic process

Molecular Function

GO:0004588 orotate phosphoribosyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
HAMAP