Conserved Site

Mannitol dehydrogenase, conserved site (IPR023027)

Short name: Mannitol_DH_CS

Description

Mannitol dehydrogenases catalyse the NAD-dependent reduction of mannitol-1-phosphates as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates [PMID: 1322373]. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose [PMID: 8254318]. Several dehydrogenases have been shown [PMID: 8254318] to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase (EC:1.1.1.17) (gene mtlD), mannitol 2-dehydrogenase (EC:1.1.1.67) (gene mtlK); mannonate oxidoreductase (EC:1.1.1.57) (fructuronate reductase) (gene uxuB); Escherichia coli hypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w.

This entry represents a conserved site found in mannitol dehydrogenases.

GO terms

Biological Process

GO:0019594 mannitol metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns