Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (IPR023016)

Short name: Isoase_HisA

Overlapping homologous superfamilies

Family relationships


This protein family consists of HisA, phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, also known as 1-(5-phosphoribosyl)-5-(5-phosphoribosylamino methylideneamino) imidazole-4-carboxamide isomerase EC:, the enzyme catalyzing the fourth step in histidine biosynthesis. It is closely related to the enzyme HisF for the sixth step. Examples of this enzyme in Actinobacteria have been found to be bifunctional, also possessing phosphoribosylanthranilate isomerase activity [PMID: 12634849].

GO terms

Biological Process

GO:0000105 histidine biosynthetic process

Molecular Function

GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.