Glycerol-1-phosphate dehydrogenase, archaea (IPR023002)

Short name: G1P_dehydrogenase_arc

Overlapping homologous superfamilies


Family relationships


This entry represents archaeal glycerol-1-phosphate dehydrogenase EC: Glycerol-1-phosphate dehydrogenase is responsible for the formation of the archaeal-specific glycerophosphate backbone of phospholipids, G-1-P, from glycerone phosphate [PMID: 9348086], using either NADH or NADPH as a coenzyme [PMID: 12913312], and is primarily Zn2+-dependent in archaea [PMID: 15876564]. This is the key step in the in biosynthesis of archaeal enantiomeric phospholipids [PMID: 9419225]. One characteristic feature of archaea is that their cellular membrane has an ether linkage between the glycerol backbone and the hydrocarbon residues. The polar lipids of the members of Archaea consist of di- and tetraethers of glycerol with isoprenoid alcohols bound at the sn-2 and sn-3 positions of the glycerol moiety. The archaeal polar lipids have the enantiomeric configuration of a glycerophosphate backbone [sn- glycerol-1-phosphate (G-1-P)]. that is the mirror image structure of the bacterial or eukaryal counterpart [sn-glycerol- 3-phosphate (G-3-P)]. The absolute stereochemistry of the glycerol moiety in all archaeal polar lipids is opposite to that of glycerol ester lipids in bacteria and eukarya. This protein family is only found in Archaea [PMID: 15337120, PMID: 15066037].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0050492 glycerol-1-phosphate dehydrogenase [NAD(P)+] activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.