Thiamine phosphate synthase/TenI (IPR022998)

Short name: ThiamineP_synth_TenI

Overlapping homologous superfamilies

Domain relationships



Thiamine phosphate synthase (TPS) catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate in the thiamine biosynthesis pathway [PMID: 9139923].

TenI, a protein from Bacillus subtilis that regulates the production of several extracellular enzymes by reducing alkaline protease production belongs to this group [PMID: 1898926]. While TenI shows high sequence similarity with thiamin phosphate synthase [PMID: 15709744], the purified protein has no thiamin phosphate synthase activity. Instead, it is a thiazole tautomerase [PMID: 21534620].

This entry refers to a domain found in thiamine phosphate synthase, thiazole tautomerase and similar proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.