Pathways & interactions
Pyrimidine-specific ribonucleoside hydrolase RihA (IPR022975)
Short name: Pyrim_hydro_RihA
- Inosine/uridine-preferring nucleoside hydrolase (IPR023186)
- Pyrimidine-specific ribonucleoside hydrolase RihA (IPR022975)
The rihA gene encodes a ribonucleoside hydrolase that preferentially utilises cytidine and uridine [PMID: 11027694]. The kcat/KM for uridine is approximately 10 times higher than for cytidine, largely due to a lower KM value for uridine [PMID: 16411753]. There are two other nucleoside hydrolases with differing specificities encoded by the rihB and rihC genes [PMID: 11027694].An rihA null mutant can not use cytidine as a source of pyrimidine and the rihA and rihC genes are subject to catabolite repression [PMID: 11027694].
A crystal structure of RihA bound to the reaction product D-ribose has been solved at 1.8A resolution [PMID: 16411753].
- MF_01431 (Pyrim_hydro_RihA)