RNA-binding domain, S1 (IPR022967)

Short name: S1_dom

Overlapping homologous superfamilies

Domain relationships


The S1 domain was originally identified in ribosomal protein S1 but is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the Escherichia coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel. Conserved residues on one face of the barrel and adjacent loops form the putative RNA-binding site [PMID: 9008164].

The structure of the S1 domain is very similar to that of cold shock proteins. This suggests that they may both be derived from an ancient nucleic acid-binding protein [PMID: 9008164].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.