Preprotein translocase subunit SecE (IPR022943)

Short name: SecE

Overlapping homologous superfamilies

Family relationships


This family is the SecE (or gamma) subunit of the protein translocase SecY, known in eukaryotes as the Sec61 complex. It is required for protein translocation in the endoplasmic reticulum.

The SecY complex forms a conserved heterotrimeric integral membrane protein complex and forms a protein-conducting channel that allows polypeptides to be transferred across the cytoplasmic membrane [PMID: 14661030, PMID: 11597451]. This complex is itself a part of a larger translocase heterotrimeric complex composed of alpha, beta and gamma subunits.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.