Ribonuclease HII (IPR022898)

Short name: RNase_HII

Overlapping homologous superfamilies

Family relationships


Ribonuclease HII is involved in the degradation of the ribonucleotide moiety on RNA-DNA hybrid molecules carrying out endonucleolytic cleavage to 5'-phospo-monoester [PMID: 21095591, PMID: 11254381]. This entry is specific for ribonuclease HII. Several bacteria, such as Bacillus subtilis, have two different type II RNases H, RNases HII and HIII [PMID: 9241229]; double deletion of these leads to cellular lethality. It appears that type I and type II RNases H also have overlapping functions in cells, as over-expression of Escherichia coli RNase HII can complement an RNase HI deletion phenotype [PMID: 17322199]. In Leishmania mitochondria, of the four distinct RNase H genes (H1, HIIA, HIIB, HIIC), HIIC is essential for the survival of the parasite and thus can be a potential target for anti-leishmanial chemotherapy [PMID: 15978682]. Ribonuclease H (RNase H) is classified into two families, type I (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type II (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H endonucleolytically hydrolyzes an RNA strand when it is annealed to a complementary DNA strand in the presence of divalent cations, in DNA replication and repair [PMID: 19228198].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004523 RNA-DNA hybrid ribonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd07182 (RNase_HII_bacteria_HII_like)