Family

Condensin complex subunit 2/barren (IPR022816)

Short name: Condensin_barren_su2

Family relationships

None.

Description

This entry represents eukaryotic condensin complex subunit 2 proteins. Included in this group are several Barren protein homologues from several eukaryotic organisms. In Drosophila Barren (barr) is required for sister-chromatid segregation in mitosis. barr encodes a novel protein that is present in proliferating cells and has homologues in yeast and human. Mitotic defects in barr embryos become apparent during cycle 16, resulting in a loss of PNS and CNS neurons. Centromeres move apart at the metaphase-anaphase transition and Cyclin B is degraded, but sister chromatids remain connected, resulting in chromatin bridging. Barren protein localises to chromatin throughout mitosis. Colocalisation and biochemical experiments indicate that Barren associates with Topoisomerase II throughout mitosis and alters the activity of Topoisomerase II. It has been suggested that this association is required for proper chromosomal segregation by facilitating the decatenation of chromatids at anaphase [PMID: 8978614].

GO terms

Biological Process

GO:0007076 mitotic chromosome condensation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000796 condensin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF
Pfam