Family

Wings apart-like protein (IPR022771)

Short name: WAPL_prot

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry contains sequences expressed in eukaryotic organisms (metazoa, fungi, plants) bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure [PMID: 10747063]. hWAPL (Q7Z5K2), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein [PMID: 15150110]. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death [PMID: 15150110].

This entry includes proteins from metazoa, fungi and plants.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam