Domain

Wings apart-like protein, C-terminal (IPR022771)

Short name: WAPL_C

Overlapping homologous superfamilies

Domain relationships

None.

Description

This entry represents the conserved region of D. melanogaster wings apart-like protein, WAPL. It is involved in the regulation of heterochromatin structure [PMID: 10747063]. hWAPL (Q7Z5K2), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein [PMID: 15150110]. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death [PMID: 15150110].

The WAPL-like proteins can be found in metazoa, fungi and plants.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam