Fascin domain (IPR022768)

Short name: Fascin-domain

Overlapping homologous superfamilies

Domain relationships



This family consists of several eukaryotic fascin or singed proteins. The fascins are a structurally unique and evolutionarily conserved group of actin cross-linking proteins. Fascins function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles. The cortical structures, which include filopodia, spikes, lamellipodial ribs, oocyte microvilli and the dendrites of dendritic cells, have roles in cell-matrix adhesion, cell interactions and cell migration, whereas the cytoplasmic actin bundles appear to participate in cell architecture [PMID: 11948621]. Dictyostelium hisactophilin, another actin-binding protein, is a submembranous pH sensor that signals slight changes of the H+ concentration to actin by inducing actin polymerisation and binding to microfilaments only at pH values below seven [PMID: 11948621]. Members of this family are histidine rich, typically contain the repeated motif of HHXH [PMID: 1436061].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0051015 actin filament binding
GO:0030674 protein binding, bridging

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.