Domain

Dna2/Cas4, domain of unknown function DUF83 (IPR022765)

Short name: Dna2/Cas4_DUF83

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents an uncharacterised domain found in several proteins, including DNA replication helicase Dna2, clustered regularly interspaced short palindromic repeats (CRISPR)-associated exonuclease Cas4 and putative RecB family exonuclease proteins.

Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities. Cas4 has been shown to be a 5' to 3' single stranded DNA exonuclease in Sulfolobus solfataricus [PMID: 23056615].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam