Pathways & interactions
ATP-dependent helicase Sgs1 (IPR022758)
Short name: Helicase_Sgs1
Overlapping homologous superfamilies
- HRDC-like superfamily (IPR010997)
- HRDC domain (IPR002121)
- ATP-dependent helicase Sgs1 (IPR022758)
This entry represents a domain found in the fungal Sgs1 protein.
Sgs1 is a RecQ family DNA helicase that unwinds DNA in an ATP-dependent manner. Sgs1 has a HRDC (helicase and RNaseD C-terminal) domain which modulates the helicase function via auxiliary contacts to DNA [PMID: 10647186]. It plays roles in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation [PMID: 18691965].
- PF11408 (Helicase_Sgs1)