ATP-dependent helicase Sgs1 (IPR022758)

Short name: Helicase_Sgs1

Domain relationships

  • HRDC domain (IPR002121)
    • ATP-dependent helicase Sgs1 (IPR022758)


This entry represents a domain found in the fungal Sgs1 protein.

Sgs1 is a RecQ family DNA helicase that unwinds DNA in an ATP-dependent manner. Sgs1 has a HRDC (helicase and RNaseD C-terminal) domain which modulates the helicase function via auxiliary contacts to DNA [PMID: 10647186]. It plays roles in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation [PMID: 18691965].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.