Domain

N6 adenine-specific DNA methyltransferase, N-terminal domain (IPR022749)

Short name: D12N6_MeTrfase_N

Domain relationships

None.

Description

This domain is found at the N terminus of the methylase subunit of Type I DNA methyltransferases. This domain is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. It is found in association with PF02384. Mutations in this region of EcoKI methyltransferase P08957 abolish the normally strong preference of this system for methylating hemimethylated substrate [PMID: 1833555]. The structure of this domain has been shown to be all alpha-helical.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam