Eukaryotic translation initiation factor 4G1, eIF4E-binding domain (IPR022745)

Short name: eIF4G1_eIF4E-bd

Overlapping homologous superfamilies

Domain relationships



The eukaryotic initiation factor 4G (eIF4G) is the core of a multicomponent switch controlling gene expression at the level of translation initiation. It interacts with the small ribosomal subunit interacting protein, eIF3, and the eIF4E/cap-mRNA complex in order to load the ribosome onto mRNA during cap-dependent translation.

This entry represents the eIF4E-binding domain superfamily of eIF4G [PMID: 14675538]. Binding of this domain to its substrate triggers a coupled folding transition where it forms a right-handed helical ring that wraps around the N terminus of eIF4E.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.