Domain

DNA (cytosine-5)-methyltransferase 1, replication foci domain (IPR022702)

Short name: Cytosine_MeTrfase1_RFD

Domain relationships

None.

Description

This domain is part of a cytosine specific DNA methyltransferase enzyme (DNMT). It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties [PMID: 10888872].

A structure exists for the human cytosine specific DNA methyltransferase replication foci domain [PMID: 21389349].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam