Proteinase, regulatory CLIP domain (IPR022700)

Short name: CLIP

Overlapping homologous superfamilies

Domain relationships



The CLIP domain is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The domain is restricted to the arthropoda and found in varying copy numbers (from one to five in Drosophila proteins). It is always found N-terminal to the chymotrypsin serine protease domain, which belong to MEROPS peptidase family S1A. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively [PMID: 2107028, PMID: 10696585].

The CLIP domain is present in silkworm prophenoloxidase-activating enzyme [PMID: 10066809].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.