Domain

Proteinase, regulatory CLIP domain (IPR022700)

Short name: CLIP

Domain relationships

Description

CLIP is a regulatory domain which controls the proteinase action of various proteins of the trypsin family, e.g. easter and pap2. The CLIP domain remains linked to the protease domain after cleavage of a conserved residue which retains the protein in zymogen form. It is named CLIP because it can be drawn in the shape of a paper clip. It has many disulphide bonds and highly conserved cysteine residues, and so it folds extensively [PMID: 2107028, PMID: 10696585].

This entry represents the CLIP domain and is found in association with PF00089.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam