Domain

Stonin-2, N-terminal (IPR022699)

Short name: Stonin2_N

Domain relationships

None.

Description

Stonin 2 is involved in clathrin mediated endocytosis [PMID: 18200045]. It binds to Eps15 by its highly conserved NPF motif. The complex formed has been shown to directly associate with the clathrin adaptor complex AP-2, and to localize to clathrin-coated pits (CCPs) [PMID: 18200045]. In addition, stonin2 was recently identified as a specific sorting adaptor for synaptotagmin, and may thus regulate synaptic vesicle recycling [PMID: 18200045].

This entry represents the N-terminal domain of stonin-2. It is found in association with PF00928.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam