Conserved Site

Proliferating cell nuclear antigen, PCNA, conserved site (IPR022659)

Short name: Pr_cel_nuc_antig_CS


Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein [PMID: 2884104] that plays a key role in the control of eukaryotic DNA replication [PMID: 1346518]. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNA replication [PMID: 2565339]. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes [PMID: 1671766]. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.

Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [PMID: 10542158, PMID: 10438605] and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses.

This entry represents two conserved regions located in the N-terminal section. The second one has been proposed to bind DNA.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns