XPA, C-terminal (IPR022656)

Short name: XPA_C

Overlapping homologous superfamilies

Domain relationships



Xeroderma pigmentosum (XP) [PMID: 8160271] is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-A is the most severe form of the disease and is due to defects in a 30kDa nuclear protein called XPA (or XPAC) [PMID: 1918083]. The sequence of the XPA protein is conserved from higher eukaryotes [PMID: 1764072] to yeast (gene RAD14) [PMID: 1741034]. XPA is a hydrophilic protein of 247 to 296 amino-acid residues which has a C4-type zinc finger motif in its central section.

This entry represents the uncharacterised C-terminal domain of the XPA protein.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.