Conserved Site

Zinc finger, XPA-type, conserved site (IPR022652)

Short name: Znf_XPA_CS

Description

Xeroderma pigmentosum (XP) [PMID: 8160271] is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-A is the most severe form of the disease and is due to defects in a 30 kDa nuclear protein called XPA (or XPAC) [PMID: 1918083]. The sequence of the XPA protein is conserved from higher eukaryotes [PMID: 1764072] to yeast (gene RAD14) [PMID: 1741034]. XPA is a hydrophilic protein of 247 to 296 amino-acid residues which has a C4-type zinc finger motif in its central section.

This entry contains the zinc-finger containing region in the XPA protein. It is found N-terminal to PF05181

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
Pfam