Proliferating cell nuclear antigen, PCNA, N-terminal (IPR022648)

Short name: Pr_cel_nuc_antig_N

Overlapping homologous superfamilies


Domain relationships



Proliferating cell nuclear antigen (PCNA), or cyclin, is a non-histone acidic nuclear protein [PMID: 2884104] that plays a key role in the control of eukaryotic DNA replication [PMID: 1346518]. It acts as a co-factor for DNA polymerase delta, which is responsible for leading strand DNA replication [PMID: 2565339]. The sequence of PCNA is well conserved between plants and animals, indicating a strong selective pressure for structure conservation, and suggesting that this type of DNA replication mechanism is conserved throughout eukaryotes [PMID: 1671766]. In Saccharomyces cerevisiae (Baker's yeast), POL30, is associated with polymerase III, the yeast analog of polymerase delta.

Homologues of PCNA have also been identified in the archaea (known as DNA polymerase sliding clamp) [PMID: 10542158, PMID: 10438605] and in Paramecium bursaria Chlorella virus 1 (PBCV-1) and in nuclear polyhedrosis viruses.

The N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated to form a closed ring encircling duplex DNA [PMID: 8001157].

GO terms

Biological Process

GO:0006275 regulation of DNA replication

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.