Microcystin synthetase, domain of unknown function (IPR022583)

Short name: Microcystin_synth_DUF

Overlapping homologous superfamilies


Domain relationships



This domain of unknown function is found in cyanobacteria and is approximately 40 amino acids in length. It is found in association with PF00501, PF00668, PF00550, and PF08242 and contains a conserved YAN motif. This region is found in microcystin synthetase, which is one of a number of proteins involved in microcystin toxin synthesis [PMID: 12700256]. Microcystins form a large family of small cyclic heptapeptides harbouring extensive modifications in amino acid residue composition and functional group chemistry. These peptide hepatotoxins contain a range of non-proteinogenic amino acids and unusual peptide bonds, and are typically N-methylated. They are synthesized on large enzyme complexes consisting of non-ribosomal peptide synthetases and polyketide synthases [PMID: 18375794].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.