Family

Cox20 (IPR022533)

Short name: Cox20

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

Complex IV (CIV) is a copper-heme oxidase that couples electron transfer from cytochrome c to oxygen with proton extrusion across the inner membrane to contribute to the proton gradient required for ATP generation. This entry includes fungal mitochondrial complex IV assembly factor Cox20 [PMID: 10671482] and its homologues (also known as (FAM36A) in metazoa [PMID: 23125284].

Human CIV is formed by three catalytic core subunits (COX1/2/3). COX20 has been found to form a complex with SCO1, SCO2, and newly synthetized COX2. It may act as a chaperone in the early steps of COX2 maturation [PMID: 24403053].

GO terms

Biological Process

GO:0009060 aerobic respiration
GO:0033617 mitochondrial respiratory chain complex IV assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005743 mitochondrial inner membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam
PIRSF
PRINTS