Peptidase T1A, proteasome beta-subunit, actinobacteria (IPR022483)

Short name: Pept_T1A_Psome_suB_actinobac

Overlapping homologous superfamilies

Family relationships



Threonine peptidases are characterised by a threonine nucleophile at the N terminus of the mature enzyme. The threonine peptidases belong to clan PB or are unassigned, clan T-. The type example for this clan is the archaean proteasome beta component of Thermoplasma acidophilum.

Members of this family are the beta subunit of the 20S proteasome as found in Actinobacteria such as Mycobacterium, Rhodococcus, and Streptomyces. In Streptomyces, maturation during proteasome assembly was shown to remove a 53-amino acid propeptide. Most of the length of the propeptide is not included in this model.

Proteins in this entry are threonine peptidases belonging to MEROPS peptidase family T1 (clan PB(T)), subfamily T1A.

GO terms

Biological Process

GO:0010498 proteasomal protein catabolic process

Molecular Function

GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.