Active Site

6-pyruvoyl tetrahydropterin synthase, cysteine active site (IPR022470)

Short name: PTPS_Cys_AS


6-pyruvoyl tetrahydropterin synthase (EC: (PTPS) [PMID: 8137809] catalyzes the second step in the biosynthesis of tetrahydrobiopterin (BH4); a complex rearrangement of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. PTPS is a small protein of about 145 residues and forms a homooligomeric complex of two trimers assembled in a head-to-head fashion. It binds a magnesium atom which is ligated by three histidine residues. Three residues are implicated in the catalytic mechanism: a cysteine, a histidine and a glutamate.

This entry contains the active site cysteine and two of the three magnesium ligands.

GO terms

Biological Process

GO:0006729 tetrahydrobiopterin biosynthetic process

Molecular Function

GO:0003874 6-pyruvoyltetrahydropterin synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns