Conserved Site

Neurohypophysial hormone, conserved site (IPR022423)

Short name: Neurohypophysial_hormone_CS

Description

Oxytocin (or ocytocin) and vasopressin [PMID: 3147712] are small (nine amino acid residues), structurally and functionally related neurohypophysial peptide hormones. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland while vasopressin has a direct antidiuretic action on the kidney and also causes vasoconstriction of the peripheral vessels. Like the majority of active peptides, both hormones are synthesized as larger protein precursors that are enzymatically converted to their mature forms. Peptides containing this conserved site are also found in birds, fish, reptiles and amphibians (mesotocin, isotocin, valitocin, glumitocin, aspargtocin, vasotocin, seritocin, asvatocin, phasvatocin), in worms (annetocin), octopi (cephalotocin), locust (locupressin or neuropeptide F1/F2) and in molluscs (conopressins G and S) [PMID: 7591488].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005185 neurohypophyseal hormone activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE patterns