Homologous Superfamily

Formiminotransferase catalytic domain superfamily (IPR022384)

Short name: FormiminoTrfase_cat_dom_sf

Overlapping entries


This entry represents the formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD), which forms a homodimer, with each protomer being comprised of two subdomains. Each subdomain has the structure consisting of an alpha/beta sandwich with antiparallel beta-sheet in the form (beta-alpha-beta)x2. Tetrahydrofolate (THF)-dependent glutamate formiminotransferase is involved in the histidine utilization pathway. This enzyme interconverts L-glutamate and N-formimino-L-glutamate. The enzyme is bifunctional as it also catalyzes the cyclodeaminase reaction on N-formimino-THF, converting it to 5,10-methenyl-THF and releasing ammonia; part of the process of regenerating THF. This model covers enzymes from metazoa as well as Gram-positive bacteria and archaea. In humans, deficiency of this enzyme results in a disease phenotype [PMID: 12815595]. The crystal structure of the enzyme has been studied in the context of the catalytic mechanism [PMID: 10673422].

This superfamily represents both individual subdomains of the formiminotransferase catalytic domain.

GO terms

Biological Process

GO:0008152 metabolic process

Molecular Function

GO:0005542 folic acid binding
GO:0016740 transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.