GCR1-cAMP receptor (IPR022343)

Short name: GCR1-cAMP_receptor

Overlapping homologous superfamilies


Family relationships


Heterotrimeric G protein-mediated signalling via activated 7-transmembrane (7TM) serpentine receptors is well known in a range of organisms, but evidence for the existence of this pathway in plants has been elusive. Over the years, however, evidence that G proteins are involved in signal transduction in plants has been accumulating, leading several researchers to seek plant 7TM receptors.

The first tangible evidence for a plant 7TM receptor came through an analysis of the expresssed sequence tag database, dbEST. This revealed an Arabidopsis thaliana gene (GCR1) that encodes a protein with 7 predicted TM domains, and other features characteristic of known 7TM receptors [PMID: 9370348, PMID: 9512416]. The amino acid sequence of GCR1, however, is unusual in that it shows similarity to receptors from three different 7TM families [PMID: 9370348, PMID: 9512416], sharing greatest levels of similarity with the Dictyostelium cAMP receptors.

It has been suggested that the cAMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes [PMID: 3047871, PMID: 8436297, PMID: 8382181].

GCR1 is expressed at low levels in the roots, stems and leaves of Arabidopsis. Studies using transgenic Arabidopsis have suggested a functional role for GCR1 in cytokinin signal transduction [PMID: 9512416].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.