Tumour necrosis factor receptor 16 (IPR022325)

Short name: TNFR_16

Overlapping homologous superfamilies


Family relationships



The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [PMID: 7917108]. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding [PMID: 8387891].

Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [PMID: 15500863]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [PMID: 11239407, PMID: 9826575].

TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis [PMID: 15500863]. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease [PMID: 9826574].

TNF receptor 16 (also known as nerve growth factor receptor (NGFR) and p75NTR)) acts as a low affinity receptor for neurotrophins. The receptor mediates a variety of contradictory cellular functions, including cell survival or apoptosis, promotion or inhibition of axonal growth, and facilitation or attenuation of proliferation, depending on the cellular context [PMID: 18199491]. The receptor may also play a role in inflammation, and has been implicated in the pathogenesis of asthma [PMID: 17716721].

A single partial match was also found, B4E096, a translated human cDNA sequence that fails to match motifs 1 and 2.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.