Family

Tumour necrosis factor receptor 18 (IPR022318)

Short name: TNFR_18

Family relationships

None.

Description

The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain -a region that contains many cysteine residues arranged in a specific repetitive pattern [PMID: 7917108]. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding [PMID: 8387891].

Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [PMID: 15500863]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [PMID: 11239407, PMID: 9826575].

TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis [PMID: 15500863]. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease [PMID: 9826574].

TNF receptor 18 is also known as glucocorticoid-induced TNFR family-related gene (GITR) and activation-inducible TNFR family member (AITR). Expression of the receptor by T-lymphocytes has been shown to have an anti-apoptotic effect, indicating that it may play a role in the regulation of T-cell receptor-mediated cell death [PMID: 9177197].

GO terms

Biological Process

GO:0043066 negative regulation of apoptotic process

Molecular Function

GO:0005031 tumor necrosis factor-activated receptor activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PRINTS