Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase (IPR022284)

Short name: GPAT/DHAPAT

Overlapping homologous superfamilies


Family relationships


This entry represents the Glycerol-3-phosphate O-acyltransferase/dihydroxyacetone phosphate acyltransferase (GPAT/DAPAT) family.

This entry includes PlsB, a GPAT from E-coli. In many bacteria, PlsB is not found, and appears to be replaced by a two enzyme system for 1-acyl-glycerol-3-phosphate biosynthesis, the PlsX/Y system IPR003811 [PMID: 16294310].

In humans, there are two isoforms of GPAT, one located in the mitochondrial outer membrane and the other in the endoplasmic reticulum [PMID: 4697393]. This entry includes the mitochondrial isoform, GPAT1 and GPAT2.

Dihydroxyacetonephosphate acyltransferase (DHAPAT) catalyses the first step in the biosynthesis of ether phospholipid plasmalogen, and may play also a significant role in nonether glycerolipid biosynthesis [PMID: 12874108, PMID: 15687349]. In humans, mutations in DHAPAT results in the genetic disorder rhizomelic chondrodysplasia punctata type 2, characterised by rhizomelic shortening of femur and humerus, cataract,and severe mental retardation [PMID: 9536089].

GO terms

Biological Process

GO:0044255 cellular lipid metabolic process

Molecular Function

GO:0008374 O-acyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.