ATP-dependent protease, HslV subunit (IPR022281)

Short name: ATP-dep_Prtase_HsIV_su

Overlapping homologous superfamilies

Family relationships


ATP-dependent protease complexes are present in all three kingdoms of life, where they rid the cell of misfolded or damaged proteins and control the level of certain regulatory proteins. They include the proteasome in Eukaryotes, Archaea, and Actinomycetales and the HslVU (ClpQY, clpXP) complex in other eubacteria. Genes homologues to eubacterial HslU (ClpY, clpX) have also been demonstrated in to be present in the genome of trypanosomatid protozoa [PMID: 12446803].

The prokaryotic ATP-dependent proteasome is coded for by the heat-shock locus VU (HslVU). It consists of HslV, a peptidase, and HslU (IPR004491), the ATPase and chaperone belonging to the AAA/Clp/Hsp100 family. The crystal structure of Thermotoga maritima HslV has been determined to 2.1-A resolution. The structure of the dodecameric enzyme is well conserved compared to those from Escherichia coli and Haemophilus influenzae [PMID: 12646382, PMID: 12823960].

This entry represents the HslV peptidase subunit of the ATP-depdendent HSIVU protease complex found in bacteria and some lower eukaryotes.

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0009376 HslUV protease complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.