SOCS4/SOCS5 domain (IPR022252)

Short name: SOCS4/SOCS5_dom

Overlapping homologous superfamilies


Domain relationships



Suppressors of cytokine signaling (SOCS) proteins play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms. They share a similar domain organisation, with a central SH2 domain and a conserved C-terminal SOCS box. In contrast, the N-terminal domains vary in length and amino acid sequence. In the case of SOCS4-7, the N-terminal domain accounts for a large proportion of the protein [PMID: 22423360].

This entry represents a conserved region in the N-terminal domains of SOCS4 and 5. This domain is approximately 60 amino acids in length. It is found in association with PF07525, PF00017.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.