Mitotic-spindle organizing protein 1 (IPR022214)

Short name: MZT1

Overlapping homologous superfamilies


Family relationships



MOZART1 or Mzt1 is a component of the gamma-tubulin complex and is required for its recruitment to the microtubule organizing centre in humans and yeast [PMID: 20360068, PMID: 24006493, PMID: 23885124]. This function is conserved in plant homologues, known as gamma-tubulin complex protein 3 (GCP3)-interacting proteins (GIPs) [PMID: 18178112, PMID: 22404201]. Studies in plant homologues GIP1 and GIP2 indicate that they play a major role in nuclear envelope shaping in both cycling and differentiated cells [PMID: 24570680] and that they are essential for centromere architecture [PMID: 26124146, PMID: 26517054].

GO terms

Biological Process

GO:0033566 gamma-tubulin complex localization

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0008274 gamma-tubulin ring complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.