Pre-mRNA splicing factor (IPR022209)

Short name: CWC25

Overlapping homologous superfamilies


Family relationships



This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with PF10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.