E3 Ubiquitin ligase, GIDE-type (IPR022170)

Short name: GIDE

Overlapping homologous superfamilies


Family relationships



This family includes mitochondrial ubiquitin ligase activator of NFKB 1 (MULAN, also known as GIDE) and in ubiquitin E3 Ligase SP1.

GIDE exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations [PMID: 18591963]. It plays a role in the control of mitochondrial morphology, promotes mitochondrial fragmentation and influences mitochondrial localisation [PMID: 18207745]. When over-expressed in human cells, it activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis [PMID: 18591963].

Ubiquitin E3 ligase SP1 associates with TOC (translocon at the outer envelope membrane of chloroplasts) complexes and mediates ubiquitination of TOC components, promoting their degradation. SP1-mediated regulation of chloroplast protein import contributes to the organellar proteome changes that occur during plant development [PMID: 23118188]. It is also important for stress tolerance in plants [PMID: 26387714].

GO terms

Biological Process

GO:0006996 organelle organization
GO:0016567 protein ubiquitination

Molecular Function

GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.